Does progesterone help reduce or get rid of Fibroids?

Yes, progesterone can be beneficial if addressed promptly with the right treatment. The larger the fibroids, the more time it will take for them to respond. Fibroids are non-cancerous, typically painless tumours located in the uterus, composed of muscle and connective tissue. They originate from oxidative stress and can start as tiny formations, eventually growing to the size of a grapefruit or even larger, occasionally occupying the entire uterus. Pregnancy decreases the likelihood of new fibroids developing, likely due to the elevated progesterone levels during this period, which seem to offer a protective effect.

Progesterone plays a vital role in curtailing the growth of fibroids by inhibiting both the hormone estrogen and the enzyme metalloproteinase. While estrogen promotes the thickening of the uterine lining, it also fosters the development of fibroids. Yet, due to the decreased levels of progesterone that accompany fibroids, the estrogen remains unopposed, allowing it to persistently accumulate in the uterine lining.

Fibroids, along with Endometriosis and PCOS, are linked to oxidative stress, and an amino acid known as N-Acetyl-L-Cysteine (NAC) has demonstrated remarkable effectiveness. Cysteine serves as a potent antioxidant, aiding in the chelation of heavy metals. Additionally, it significantly benefits hair, skin, nails, and much more. Vitamin D3 is also a strong antioxidant that contributes to the reduction of fibroids. Please refer to the references. Addressing Inflammation is essential.

The body contains an enzyme known as metalloproteinase, which is responsible for breaking down proteins. In the uterus, this enzyme becomes active when progesterone levels fall at the end of the menstrual cycle, leading to the breakdown of the uterine lining and consequently, the occurrence of monthly periods. While progesterone does inhibit this enzyme, persistently low levels of progesterone mean there is no longer anything to restrain it. As a result, the uterine lining continues to degrade even as estrogen promotes its growth, creating a cyclical issue. This cycle is characterized by very heavy bleeding, the presence of clots, and prolonged periods with only brief intervals in between—common signs associated with fibroids.

To break this cycle, it is advisable to begin with high doses of progesterone, approximately 200mg per day, or perhaps even more. Naturally, this process requires patience, as the fibroid(s) have taken time to develop. Some women may encounter symptoms of estrogen dominance when they first start using progesterone. Interestingly, men can also experience these symptoms, in addition to the typical ones seen in women.

All studies examining progesterone that demonstrated favourable outcomes utilized dosages ranging from 200mg to 500mg per day or 6ml to 12ml of Natpro Progesterone Cream daily. In some cases, dosages may reach as high as 600mg per day, depending on the severity of the condition. It’s recommended to apply the cream twice daily to maintain consistent levels. For optimal results, use the cream every day without interruptions until there is a noticeable improvement, after which you can begin to follow your menstrual cycle. If you believe you are stable enough to reduce your usage, please do so gradually. For guidance, refer to the sections First Time Users and  How to use Natpro Progesterone Cream. Reducing your dosage too quickly may result in the reemergence of symptoms.

Approximately 15 to 20% of women of reproductive age develop fibroids, with the incidence increasing significantly among those in their mid-thirties to forties, where it affects 30 to 40%. This period is characterized by elevated estrogen levels as well as a decline in progesterone. Fibroids frequently lead to heavy, irregular, and often painful menstrual cycles. However, it is understood that these fibroids tend to diminish after menopause, as estrogen levels decrease.

Supplemental progesterone is frequently effective in diminishing fibroids. When they are not excessively large, these fibroids are gradually reabsorbed by the body, a process that can take anywhere from three to twelve months.  Larger fibroids unfortunately would require surgery.

Progesterone therapy is frequently effective in alleviating heavy bleeding and pain when they occur. Presently, medical interventions include hysterectomy, uterine artery embolization (UAE), or laparoscopic myomectomy (LM) to eliminate these issues, alongside anti-inflammatory medications for pain management and oral contraceptives to regulate heavy bleeding. Nonetheless, the use of progesterone can help avoid these procedures significantly and plays a crucial role in reducing symptoms.

Removing fibroids won’t significantly resolve the issue; it’s essential to tackle the oxidative stress by incorporating antioxidants into your regimen.

Some Fibroid symptoms:

• fullness or pressure in the abdomen
• pain with periods
• gas
• frequent urination
• heavy bleeding, often with clots

AVOID all forms estrogens, as they can encourage fibroid growth; steer clear of sugar and artificial sweeteners, as well as all processed foods that contain sugar; avoid refined grains, especially wheat; skip carbonated beverages, including diet options; eliminate fruit juices; pastries; cakes; white bread; canned goods; sauces; sweets; large meals; oxidized fats (such as margarine, refined oils, saturated fats, and fried foods, particularly fried animal products); pasteurized and homogenized milk; and stimulants like alcohol, coffee, and black tea.

Equally important factors include VITAMIN D3 see here. A deficiency can result in various health issues, but when paired with progesterone, it can greatly improve our quality of life. Take the time to read the information about Vitamin D3 and view the related videos. Vitamin D3 is known to help in reducing fibroids. Be sure to have your vitamin D3 levels tested. Levels should be optional. Additionally, a deficiency of taurine has been linked to endometrial cancer, cystic endometrial hyperplasia, fibromyoma (fibroids), and dysfunctional uterine bleeding see here.