OSTEOPOROSIS

Osteoporosis is impacting a significant number of individuals in the West, with 1 in 3 women and 1 in 12 men being affected. This condition arises when the absorption of old minerals from the bones into the bloodstream surpasses the formation of new mineral deposits. Osteoblast cells are responsible for creating new bone, while osteoclast cells are tasked with breaking down the old bone.

Osteoblasts are the immature bone cells located on the surfaces of bones. They produce a protein primarily composed of Type 1 collagen, which forms the matrix where minerals are deposited. The activity of osteoblasts is stimulated by progesterone and testosterone. Once they mature, these bone cells are referred to as osteocytes, originating from the osteoblasts.  They are specialized cells that play a crucial role in bone resorption, facilitating the removal of old bone to allow for the formation of new bone tissue. Estrogen inhibits the activity of osteoclasts.

You are at risk for osteoporosis if you are:

  • deficient in vitamin D3, most at risk are those who avoid or cover up when in the sun
  • chronically deficient in calcium
  • deficient in Magnesium, zinc, boron and vitamin K2
  • deficient in protein
  • exercise excessively - marathon runners/ballet dancers
  • under exercise
  • are or were anorexics and bulimics
  • smoke
  • drink excessive amounts of alcohol and coffee, or carbonated soft drinks which contain large amounts of phosphorus
  • deficient in certain amino sugars, particularly proteoglycans (PGs) and glycosaminoglycans (GAGs)
  • have a low level of stomach acid and digestive enzymes, which is very prevalent in the elderly
  • are taking or have taken steroids, i.e. cortisone and the contraceptive pill, or anti-seizure or anticoagulant drugs
  • have or had thyroid disease
  • had a loss of menstruation for greater than 6 months, other than pregnancy
  • eat a western diet of processed foods and refined grains

Consuming excessive amounts of calcium will NOT enhance bone density; instead, it may lead to its accumulation in soft tissues. Critical nutrients such as magnesium, vitamin D3, and vitamin B6 are also necessary, as calcium cannot effectively integrate into the bones without them.

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While normal calcium levels in the bones paired with low magnesium levels can lead to unusual bone calcification, this condition heightens the risk of fractures. Elevated calcium levels in the bloodstream have been associated with the formation of gallstones and kidney stones, the development of arthritic spurs, and calcification in the arteries and brain. Additionally, this can contribute to depression, issues with blood glucose levels, and an increased risk of myocardial infarction.

Before starting calcium supplements, it is crucial to conduct a hair analysis to determine the levels of calcium and magnesium in your system. Excessive intake of these minerals can lead to toxicity, with severe depression being a potential consequence of elevated levels. A hair analysis will identify the specific mineral that needs to be supplemented. Typically, magnesium levels are insufficient due to its scarcity in most soils, which in turn affects our food supply. Additionally, magnesium is a vital co-factor for vitamin D3.. See Trace Elements - Hair Mineral Analysis

The amino acid taurine is vital in regulating the flow of calcium, magnesium, potassium and sodium into and out of all cells.

Research has shown that a high protein diet increases bone strength by aiding in calcium deposition.

Have your Homocysteine levels checked as it has been implicated in osteoporosis, if high, take the following nutrients to lower it:

  • folic acid
  • vitamin B2
  • vitamin B6
  • vitamin B12
  • TMG (tri-methyl glycine)
  • zinc

Reduce your intake of salt and sugar, as elevated levels can lead to the body excreting greater quantities of calcium.

It is commonly thought that osteoporosis in women primarily results from the loss of estrogen that occurs at menopause. However, evidence suggests that this process can actually begin in women during their mid-thirties, a time when they are still producing significant levels of estrogen, casting doubt on that belief. In reality, certain women may experience a decline of up to 25% in their bone density by the time they arrive at menopause.

Administering estrogen can slow bone loss for as long as five years; however, its effectiveness diminishes after this period, while the risk of breast cancer escalates to 40%. Upon discontinuation of estrogen, the bones rapidly regress to their prior condition.

How does progesterone help? Its influence on osteoblast cells makes it a key player in bone formation. In contrast to estrogen, when the treatment ceases, the bones continue to remain robust, eliminating any cancer risk. Additionally, progesterone promotes the incorporation of thymidine into DNA and enhances proline incorporation into collagen proteins.

Vitamin D3 is essential, so have a blood test done to ascertain your level. The test should only be done for 25-dyroxyvitamin D, also called calcidiol - D3. 

As many as 50% of individuals may experience a deficiency, particularly those residing in areas with limited sunlight, those living beyond 34 degrees north or south of the equator, individuals who work indoors, and those with darker skin who spend minimal time in the sun are at risk.

It is advised that the minimum daily intake of vitamin D3 be set at 5,000iu's However, recent studies suggest that the optimal dosage should be 10,000iu's per day.- see here.

This is an indication of levels of vitamin D3 found in the blood: 

  • Sufficient 70 - 100ng/ml or 175 - 250nmol/L
  • Hypovitaminosis less than 30ng/ml or 75mnol/L
  • Deficiency less than 25ng/ml or 62nmol/L

Some information on the roles of Vitamin D3, Magnesium and Vitamin K2 MK:7 (no soy)

Vitamin D3 facilitates the absorption of calcium from the diet, while Vitamin K2 ensures that calcium is directed to essential areas like bones and teeth, rather than accumulating in organs, arteries, muscles, and soft tissues where it may lead to health complications. It's Magnesium's role to maintain proper calcium placement. Together, Vitamin D3, Magnesium, and Vitamin K2 are indispensable!

Note on calcium: We do not need to supplement with calcium, unless you are chronically deficient. Please view these excellent videos, they are well worth the view. Death by Calcium and Too Much Calcium.

Progesterone and Osteoporosis

Depending on how severe symptoms are, women should use between 100-200mg progesterone per day, men should use between 10-100mg progesterone per day. For more information please see How to use Progesterone.

Please note: before using progesterone for the first time please read Estrogen Dominance.

Here is a list of some of the nutrients needed to build bone:

  • vitamin D3
  • magnesium
  • phosphorus
  • boron
  • zinc
  • taurine
  • N-acetyl cysteine (NAC)
  • vitamin C
  • vitamin B6
  • glucosamine sulphate or hydrochloride
  • chondroitin
  • vitamin K2
  • probiotics (to increase vitamin K2 - fermented veg is the absolute best source)
  • protein
  • proteoglycans
  • glycosaminoglycans

Avoid

  • all forms of estrogen, the Pill, progestin only, HRT, tamoxifen, soy, unless fermented
  • tap water is now tainted with prescription medications, including estrogen from contraceptives and hormone replacement therapy, as well as industrial estrogen mimics. It is advisable to drink only filtered water.
  • Fluoride, even when found in toothpaste, has been highlighted in numerous studies to increase bone density; however, it paradoxically weakens the bones, thereby elevating the risk of hip fractures.
  • bisphosphonate medications may elevate the risk of fractures, oesophagal cancer, dyspepsia, nausea, abdominal pain, erosive esophagitis, oesophagal ulcers, and could also heighten the risk of atypical femur fractures.

Reading all labels on containers, particularly for food and cosmetics, is crucial. Seek out natural alternatives for body care products, as many contain significant levels of endocrine disruptors.

  • For information on toxins found in skin care products please visit Skin Deep.
  • For information on endocrine disruptors please visit.  For more information see Our Stolen Future.


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